CUSBO (Center for Ultrafast Science and Biomedical Optics) groups together the research activities performed at the Department of Physics of Politecnico of Milan in the field of lasers and time-domain spectroscopy.

CUSBO also relies on the collaboration with the Centre for Ultraintense and Ultrafast Optical Science (ULTRAS-INFM) and the Institute of Photonics and Nanotechnology (IFN), both belonging to the National Research Council (CNR) and located in the same Department.


Using the latest all solid state laser technologies together with most advanced optical techniques different research activities are performed at CUSBO, namely on:

  • ultrashort pulse generation;
  • non-linear optics;
  • high intensity laser-matter interactions;
  • attosecond science;
  • study of ultrafast processes in quantum confined materials and systems;
  • development photonics devices;
  • physics of photon propagation in highly scattering media;
  • non-invasive time-resolved broad-band spectroscopy of duffusive media;
  • time-resolved diffusive optical imaging;
  • broad-band fluorescence lifetime spectroscopy and imaging.


CUSBO provides state of the art laser sources capable of generating extremely short light pulses (few optical cycles) widely tunable from the near-infrared up to the visible-UV in connection with a variety of high resolution measurement techniques for ultrafast spectroscopy. This capability have been recently extended into the soft X-ray region with attosecond pulse generation. CUSBO provides state of the art broad-band instrumentation for optical characterisation of biological tissues, in vitro study of single cells, in vivo pharmaco-kinetics studies and non-invasive functional imaging.

The staff personnel at CUSBO is composed by Politecnico Faculty members and researchers belonging to ULTRAS-INFM and IFN. The personnel at the infrastructure is trained to the use of the latest ultrafast laser technologies as well as to the applications of unconventional measurement systems to biomedical investigation. CUSBO is open to national and international research groups willing to perform experiments. CUSBO belongs to the European Network of Large-Scale Laser Infrastructures "LASERLAB-Europe", which participates to the european program "FP7-Capacities", dedicated to transnational access. This program supports living and traveling expenses of european users, which wish to apply for access to the infrastructures: more information can be found at


Research areas:



Director: Sandro De Silvestri

Secretariat: Roberta Bertoli